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在对地方性克汀病(下称地克病)的研究中,许多学者发现甲状腺有不同程度的发育不良或损伤,推测可能为自身免疫所致。王维忱等还发现部分地克病人血清IgG含量较正常者高,认为可能系甲状腺球蛋白抗体(TGab)。为了探讨供给碘盐四年后的湘西北地区神经型地克病人的甲状腺功能及其自身抗体和体液免疫水平,作者采用病例对照研究,运用放射免疫等手段,对96例神经型地克病人的血清T_3、T_4、TSH、TGab、甲状腺微粒体抗体(TMab)、IgG、IgA、IgM进行了测定,现报告如下。
In the study of endemic cretinism (hereinafter referred to as Dick’s disease), many scholars found that the thyroid gland has varying degrees of dysplasia or damage, presumably due to autoimmunity. Wang Wei Chen also found that some grams of patients with serum IgG levels higher than normal, that may be thyroglobulin antibody (TGab). In order to investigate the thyroid function, autoantibody and humoral immunity of neurogenic Dickel patients in the northwestern part of Hunan Province after four years of supplying iodized salt, the author used case-control study and radioimmunoassay to detect the thyroid function of 96 patients with neurological Dick disease Serum T_3, T_4, TSH, TGab, thyroid microsomal antibody (TMab), IgG, IgA, IgM were measured, are as follows.