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目的:探讨基质金属蛋白酶9(MMP-9)和嗜酸粒细胞(EOS)在鼻息肉组织的表达及其对预后的影响。方法:分别应用免疫组织化学和苏木精-伊红染色的方法,研究预后好(愈合组)和预后差(复发组)的鼻息肉组织中MMP-9和EOS的表达。结果:复发组鼻息肉组织中MMP-9的表达显著高于愈合组,且MMP-9在以EOS为主的鼻息肉中的表达显著增高;愈合组鼻息肉患者以EOS为主的占16.67%,显著低于复发组的62.50%。结论:MMP-9在复发组及EOS组鼻息肉的高表达,提示MMP-9可能通过增加EOS在鼻黏膜局部的浸润,影响了鼻息肉的预后。MMP-9可能作为鼻息肉复发的危险因子之一。
Objective: To investigate the expression of matrix metalloproteinase 9 (MMP-9) and eosinophils (EOS) in nasal polyps and its effect on prognosis. Methods: Immunohistochemistry and hematoxylin-eosin staining were used to study the expression of MMP-9 and EOS in nasal polyps with good prognosis (healing group) and poor prognosis (recurrence group). Results: The expression of MMP-9 in nasal polyps in recurrent group was significantly higher than that in the healing group, and the expression of MMP-9 in nasal polyps mainly in EOS group was significantly higher. The predominantly EOS in the healing group was 16.67% , Significantly lower than the recurrence group 62.50%. Conclusion: The high expression of MMP-9 in nasal polyps in recurrent and EOS groups suggests that MMP-9 may affect the prognosis of nasal polyps by increasing the infiltration of EOS in nasal mucosa. MMP-9 may be one of the risk factors for the recurrence of nasal polyps.