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钙拮抗剂是60年代出现的一类重要心血管药物，临床上常与地高辛（Digoxin，DGX）配伍治疗心功能不全及心律失常，但二者合用时，某些钙拮抗剂可改变地高辛的药动学过程，引起地高辛血药浓度（serumdigoxinconcentration，SDC）升高，甚至导致DGX中毒。硝苯地平、维拉帕米及地尔
Calcium antagonists are a kind of important cardiovascular drugs appearing in 1960s. They are often clinically used in combination with digoxin (DGX) to treat cardiac insufficiency and arrhythmia. However, when they are used together, certain calcium antagonists can be changed The pharmacokinetics of digoxin caused an increase in serum digoxin concentration (SDC) and even DGX intoxication. Nifedipine, verapamil, and doel