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采用组织学方法对１月龄、２月龄、老龄豫医无毛小鼠皮肤结构进行了比较，结果发现，各年龄段表皮均有一层角化过度的角质层，毛干消失，毛球结构不正常，毛囊被一些角化物质充填。但真皮层差别很大。１月龄皮肤为肉色偏红，切片可见表皮层较厚，真皮内没有包囊；２月龄皮肤为肉色，表皮层较１月龄薄，毛囊腔大，真皮深层及皮下组织内有一些大小不等的包囊；老龄鼠皮肤为淡黄色，头部和体侧形成特别皱纹和褶痕，皮肤脆性大，易撕裂，表皮层薄，角化严重，真皮层被包囊扩张。包囊直径约为２月龄的４倍，内含一些角化物和脂肪样物质
Histological methods were used to compare the skin structure of hairless mice aged 1 month, 2 months old and aged. The results showed that the epidermis of all ages had a layer of hyperkeratotic keratinized layer, the hair shaft disappeared, Not normal, hair follicles were filled with some keratin. But the dermis is very different. 1-month-old skin reddish color, sliced thick epidermis, dermis no cysts; 2-month-old skin is flesh-colored, epidermal than 1 month old, hair follicles cavity, deep dermis and subcutaneous tissue within the size Unequal cysts; aged rats skin yellow, head and body side to form special wrinkles and creases, skin brittle, easy to tear, epidermal thin, keratosis serious dermal layer is cyst expansion. Cysts diameter of about 2 months old 4 times, contains some keratin and fat-like substances