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镉是一种广泛存在于水及土壤中的毒性物质。肾脏和骨骼是镉的重要靶器官,并且研究表明镉对肾脏和骨骼的毒性可能具有相关性,即骨骼损害继发于肾脏损害,但是也有研究表明镉可能具有直接的骨毒性,包括影响成骨细胞、破骨细胞活性、干扰胶原代谢以及抑制矿化等。本文从人群、动物及细胞分子生物学等多个方面就镉对肾脏和骨骼的损害进行综述,为探讨镉的毒效应提供参考。
Cadmium is a toxic substance widely found in water and soil. Kidneys and bones are important cadmium targets, and studies have shown that cadmium may have a correlation with renal and skeletal toxicity, ie, bone damage secondary to renal damage, but studies have also shown that cadmium may have direct bone toxicity, including effects on osteogenesis Cells, osteoclast activity, interfere with collagen metabolism and inhibit mineralization. This article reviews the damage of cadmium to the kidneys and bone from many aspects such as population, animal and cell molecular biology, and provides a reference for exploring the toxic effect of cadmium.