成骨不全症（OsteogenesisImperfecta），又名兰巩膜脆骨病，是一种果及巩膜、内耳、韧带、肌位的全身性结统组织病，具有家庭遗传倾向，属少见病。虽然国内外已有报道，但此张氏家庭发病率高，分型有差异、病程短。作者归集了张氏家庭18例成骨不全症，现报告如下。1临床资料1 Osteogenesis imperfecta (Osteogenesis Imperfecta), also known as blue sclera brittle bone disease, is a kind of fruit and the sclera, inner ear, ligaments, muscle position of the general organization of the disease, with family genetic predisposition, is a rare disease. Although reported at home and abroad, but this Zhang family incidence is high, there are differences in type, short course. The author collected 18 cases of family Zhang osteogenesis imperfecta, are as follows. 1 clinical data 1