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目的:观察奥美拉唑与铋剂为中心三联合用对幽门螺杆菌(Hp)的根除效果及安全性。方法:胃粘膜Hp阳性的十二指肠溃疡患者随机分为三联组(枸橼酸铋钾120mg、阿莫西林250mg,甲硝唑200mg,各每日4次共2周,后继服枸橼酸铋钾240mg,每日2次,服2周)、四联(三联基础上加奥美拉唑20mg,2次/日,服四药1周)组,后继服奥美拉唑20mg,每日1次,服3周,Hp根除和溃疡愈合均以停药4周后胃镜复查为准。结果:四联组Hp根除率91%(38/42)和溃疡愈合率95%(40/42)高于三联组的80%(20/25)及92%(23/25),但无统计学差异。四联组副作用(17%)少于三联组(28%),差别无显著性。结论:四联疗法可获得高Hp根除率,不良反应少,疗程短,值得进一步试用。
OBJECTIVE: To observe the eradication effect and safety of omeprazole and bismuth in combination with Helicobacter pylori (Hp). Methods: Gastric mucosal Hp-positive duodenal ulcer patients were randomly divided into triple group (bismuth potassium citrate 120mg, amoxicillin 250mg, metronidazole 200mg, 4 times a day for 2 weeks, followed by citric acid Bismuth potassium 240mg, 2 times a day for 2 weeks), quadruple (triple on the basis of plus omeprazole 20mg, 2 times / day, taking four drugs for 1 week) group, followed by omeprazole 20mg, daily 1 times for 3 weeks, Hp eradication and ulcer healing were discontinued 4 weeks after gastroscopy review shall prevail. Results: The Hp eradication rate was 91% (38/42) and the ulcer healing rate was 95% (40/42) in the quadruple group compared with 80% (20/25) and 92% (23/25) in the triad group, but no statistics Differences The quadruple group had fewer side effects (17%) than the triple group (28%), with no significant difference. Conclusion: The quadruple therapy can achieve high Hp eradication rate, less adverse reactions, short course of treatment, it is worth further trial.