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Pancreatic insulin-secretingβcells are essential in maintaining normal glucose homeostasis accomplished byhighly specialized transcription of insulin gene,of which occupies up to 40%their transcriptome.Deficiency of these cells causes diabetes mellitus,a global public health problem.Although tremendous endeavors have been made to generate insulin-secreting cells from human pluripotent stem cells(i.e.,primitive cells capable of giving rise to all cell types in the body),a regenerative therapy to diabetes has not yet been established.Furthermore,the nomenclature ofβcells has become inconsistent,confusing and controversial due to the lack of standardized positive controls of developmental stagematched in vivo cells.In order to minimize this negative impact and facilitate critical research in this field,a postgenomic concept of pancreaticβcells might be helpful.In this review article,we will briefly describe howβcells were discovered and islet lineage is developed that may help understand the cause of nomenclatural controversy,suggest a post-genomic definition and finally provide a conclusive remark on future research of this pivotal cell.
Pancreatic insulin-secreting β cells are essential in maintaining normal glucose homeostasis achieved by highly specialized transcription of insulin gene, of which occupies up to 40% of their transcriptome. Deficiency of these cells causes diabetes mellitus, a global public health problem. Though tremendous endeavors have been made to generate insulin-secreting cells from human pluripotent stem cells (ie, primitive cells capable of giving rise to all cell types in the body), a regenerative therapy to diabetes has not yet been established. Morerther, the nomenclature of beta cells has become inconsistent, confusing and controversial due to the lack of standardized positive controls of developmental stagematched in vivo cells. In order to minimize this negative impact and particularly critical research in this field, a postgenomic concept of pancreatic β cells might be accurate. this review article, we will only describe how β cells were discovered and islet lineage is developed that may help underst and the cause of nomenclaural controversy, suggest a post-genomic definition and finally provide a conclusive remark on future research of this pivotal cell.