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目的:评价针刺治疗尼古丁依赖戒断后抑郁症的临床疗效.方法:选择尼古丁依赖戒断后抑郁症患者74例作为观察对象,随机分为针刺组(38例)和西药组(36例).针刺组予以针剌治疗,穴取百会、印堂、三阴交、太冲、内关、合谷,西药组给予口服氟西汀治疗,每日1次.治疗前后分别进行汉密尔顿抑郁量表( HAMD)评分,对比治疗前后HAMD评分变化及疗效.结果:针刺组和西药组治疗后HAMD评分较治疗前均有显著改善(均P＜0.05),针刺组有效率为89.5％( 34/38),西药组有效率为91.7％( 33/36),两组比较差异无统计学意义(均P＞0.05).结论:针刺治疗尼古丁依赖戒断后抑郁症疗效与口服氟西汀疗效相当.“,”Objective To evaluate the clinical efficacy of acupuncture on depression in nicotine withdrawal.Methods Seventy-four cases of depression after nicotine withdrawal were selected as the subjects in observation and they were randomized into an acupuncture group (38 cases) and a western medicine group (36 cases).In the acupuncture group,acupuncture was applied to Bǎihuì (百会GV 20),Yìntáng (印堂EX-HN 3),Sānyīnjiāo(三阴交SP 6),Tàichōng (太冲LR 3),Nèiguān（内关PC 6）and Hégǔ(合谷LI 4).In the western medicine group,Fluoxetine was prescribed tor oral administration,once per day.Hamilton Depression Scale (HAMD) was adopted for the evaluation before and after treatment separately and the changes in HAMD score as well as the efficacy were compared before and after treatment.Results HAMD score in either acupuncture group or western medicine group was improved significantly as compared with that before treatment (all P＜0.05).The effective rate was 89.5％ (34/38) in the acupuncture group and was 91.7％ (33/36) in the western medicine group.There was no statistically significant difference between the two groups (all P＞0.05).Conclusion The efficacy of acupuncture is similar to that of Fluoxetine in the treatment of depression in nicotine withdrawal.