已知克隆生长过度是肿瘤形成增殖的标志 ,依据特异性与显性免疫球蛋白和 /或Ｔ -细胞受体基因重排的检测可诊断恶性淋巴瘤。非随机基因的变异亦可用于发现肿瘤的克隆过度与进化 ,尤其是分析来源于病人杂合子的高度变异ＤＮＡ区以此作为一个特定标志。由于观察到肿瘤时半合子状 It is known that overgrowth of clones is a marker of tumor formation and proliferation, and malignant lymphomas can be diagnosed on the basis of detection of specific and dominant immunoglobulin and / or T-cell receptor gene rearrangements. Non-random gene mutation can also be used to detect overcrowding and evolution of the tumor, especially the analysis of highly variant DNA regions derived from heterozygous patients as a specific marker. Half-zygotic due to observed tumor