论文部分内容阅读
监测生后10小时左右正常新生儿34例,窒息后新生儿30列血液流变学指标和血浆中β_2—MG值.另测定24例正常新生儿分娩时脐动脉血浆中β_2—MG值.结果:窒息组新生儿较正常对照组新生儿高、低切变率下全血表观粘度和还原粘度均显著增高(P<0.01),HCT和红细胞聚集指数也较正常对照组显著增高(P<0.01),血浆粘度两组间无差异.窒息组和脐血组中β_2—MG均显著高于正常对照组(P<0.01),脐血组与窒息组间无差异.窒息组血中β_2—MG值与高切变率下全血表观粘度值呈中度正相关,r=0.62,P<0.05.窒息血粘度升高患儿并发HIE13例、颅内出血5例、NEC3例.正常新生儿并发HIE3例.研究结果提示:新生儿窒息缺氧后血粘度增高,红细胞变形能力下降,影响了组织器官的正常灌流和微循环营养物质代谢产物交换.与窒息后各种并发症的发生发展有明显关系.
Thirty-four normal neonates and 30 neonates with asphyxia were monitored at 10 hours after birth, and β_2-MG in plasma were measured.β_2-MG in umbilical artery was measured in 24 normal newborns at delivery. (P <0.01), HCT and erythrocyte aggregation index were significantly higher in asphyxia group than those in normal control group (P < 0.01) and there was no difference between the two groups in plasma viscosity.The β_2-MG in asphyxia group and umbilical cord blood group were significantly higher than those in normal control group (P <0.01), there was no difference between umbilical cord blood group and asphyxia group.β_2- There was a moderate positive correlation between MG value and apparent viscosity of whole blood under high shear rate (r = 0.62, P <0.05) .13 cases of HIE complicated with intracranial hemorrhage in 5 cases and 3 cases of NEC in children with asphyxia Complicated with HIE 3 cases.The results suggest that: neonatal asphyxia increased blood viscosity after hypoxia, decreased erythrocyte deformability, affecting the normal perfusion of tissues and organs and micro-circulation of metabolites and metabolites exchange with the development of various complications after asphyxia Obvious relationship.