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Background:With the setting up of the custodial room to infant serious illness,many infant patients with hypoxic ischemic encephalopathy(HIE) has survived.It has been reported that long term prognosis of serious HIE infant patients is bad and its percentage has gone to 73.6% (including sequela and death).Therefore how to improve these infant patients prognosis are more and more thought highly of.We exerted intervention treatments in 12 months without intermission on 27 infant patients, and got significant effects