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目的探讨体外受精-胚胎移植(IVF-ET)技术中影响胚胎着床的相关因素。方法162个IVF蛳ET周期,按治疗结局分为妊娠组和非妊娠组,用阴道超声监测其自然周期和随后的超排周期卵泡的生长发育情况,分析对治疗结局的影响。结果自然周期中各排卵类型并不影响超排周期的治疗结局。自然周期中有排卵型周期排卵日卵泡直径在妊娠组与非妊娠组间有显著性差异〔(17.65±1.72)mm,(16.83±2.52mm)〕,P<0.05。超排周期卵泡于注射人绒毛膜促性腺激素(hCG)前7d开始发动,并呈直线生长,且当这天卵泡直径<8mm时,周期妊娠率高(61.5%),但随后的各级次卵泡直径及生长速率不影响治疗结局。结论促排药物可促使多个卵泡发育,并有利于达到卵泡发育基本同步化。卵泡受体内激素调节生长情况较好的自然周期后的超排周期妊娠率高。
Objective To investigate the factors influencing embryo implantation in vitro fertilization-embryo transfer (IVF-ET) technique. Methods 162 cycles of IVF 蛳 ET were divided into pregnancy group and nonpregnant group according to the outcome of treatment. The growth of follicles in their natural cycle and subsequent superovulation was monitored by vaginal ultrasonography, and the effect on treatment outcome was analyzed. The results of the natural cycle of each type of ovulation does not affect the treatment of superovulatory cycle outcome. Ovulation follicles at ovulation cycle in the natural cycle of follicles in the pregnancy group and non-pregnancy group were significantly different 〔(17.65 ± 1.72) mm, (16.83 ± 2.52mm〕〕, P <0.05. Supraventricular follicles started 7 days before human chorionic gonadotropin (hCG) injection and grew linearly. When the diameter of follicle was less than 8mm, the rate of cycle pregnancy was high (61.5%), but the subsequent stages Follicle diameter and growth rate did not affect the treatment outcome. Conclusion promoting drugs can promote the development of multiple follicles, and help achieve the basic synchronization of follicular development. Follicle receptor hormone regulation of growth better after the natural cycle of superovulation cycle pregnancy rate.