自Rygoard和Povlson观察到人类肿瘤可以在先天性无胸腺鼠体内进行生长后,人们就广泛应用该动物作研究人类肿瘤移植及先天性无胸腺鼠免疫缺陷的模型。尽管这种鼠缺乏功能上成熟的T细胞,但仍具有对T细胞非依赖性抗原的正常应答,具有杀肿瘤细胞的巨噬细胞以及高水平的自然杀伤细胞活性。现已证明该鼠不能产生依赖T细胞的免疫应答,反映了该鼠产生IL-2有缺陷。这 Since Rygoard and Povlson have observed that human tumors can grow in congenital athymic mice, they are widely used to study models of human tumor transplants and congenital athymic immunodeficiency. Although this mouse lacks the functionally matured T cells, it still has a normal response to T cell-independent antigens, macrophages with tumor-killing cells, and high levels of natural killer cell activity. It has been demonstrated that this mouse fails to produce a T cell-dependent immune response, reflecting the mouse’s defective production of IL-2. This