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目的研究无创通气治疗急性重症支气管哮喘的效果。方法抽选2014年7月-2015年7月就诊于我院的急性重症支气管哮喘患者106例,随机法分为通气组和常规组,每组各53例。常规组给予吸氧、雾化吸入、抗炎止咳、化痰止喘、维持体液平衡等常规治疗,通气组在上述治疗基础上给予无创通气治疗。比较两组患者临床疗效,记录治疗前、治疗1 d及治疗后血心率、呼吸、血气指标(血氧分压、血二氧化碳分压)水平。结果通气组总有效率与常规组比较显著较高(94.34%vs 81.13%),差异有统计学意义(χ2=4.296,P<0.05)。两组患者治疗1 d及治疗后心率、呼吸、血氧分压、血二氧化碳分压水平均显著改善,差异有统计学意义(均P<0.05)。治疗后通气组心率、呼吸、血二氧化碳分压水平低于常规组〔(80.0±2.2)次/min、(18.6±3.5)次/min、(37.3±12.7)mm Hg vs(91.6±4.3)次/min、(24.6±5.1)次/min、(42.7±13.9)mm Hg〕,血氧分压高于常规组〔(103.1±9.4)mm Hg vs(84.7±9.3)mm Hg〕,差异有统计学意义(P<0.05)。通气组住院时间与常规组比较较短〔(13.3±5.8)d vs(18.6±7.4)d〕,差异有统计学意义(P<0.05)。结论无创通气治疗急性重症支气管哮喘能迅速改善患者呼吸、心率、血气指标水平,缩短住院时间,临床疗效显著。
Objective To study the effect of noninvasive ventilation on acute severe bronchial asthma. Methods A total of 106 patients with acute severe bronchial asthma admitted to our hospital from July 2014 to July 2015 were randomly divided into ventilated group and conventional group, with 53 cases in each group. The conventional group was given routine therapy such as inhalation of oxygen, inhalation of atomization, anti-inflammatory and cough-stopping, phlegm and stopping asthma, and maintenance of body fluid balance. The ventilation group was given non-invasive ventilation on the basis of the above treatment. The clinical efficacy was compared between the two groups. The blood glucose, respiratory rate and blood gas index (partial pressure of blood pressure and partial pressure of blood carbon dioxide) before treatment, after treatment for 1 day and after treatment were recorded. Results The total effective rate of ventilation group was significantly higher than that of conventional group (94.34% vs 81.13%), the difference was statistically significant (χ2 = 4.296, P <0.05). After treatment for 1 day and after treatment, heart rate, respiration, partial pressure of blood pressure and partial pressure of blood carbon dioxide were significantly improved in both groups (all P <0.05). Ventilation group after treatment, heart rate, respiration, blood pressure of carbon dioxide levels were lower than the conventional group (80.0 ± 2.2) / min, (18.6 ± 3.5) times / min, (37.3 ± 12.7) mm Hg vs (91.6 ± 4.3) times (24.6 ± 5.1) times / min, (42.7 ± 13.9) mm Hg〕. The partial pressure of blood oxygen was higher than that of the conventional group (103.1 ± 9.4 mm Hg vs 84.7 ± 9.3 mm Hg) Significance (P <0.05). The duration of hospitalization in the ventilation group was shorter than that in the conventional group [(13.3 ± 5.8) d vs (18.6 ± 7.4) days], the difference was statistically significant (P <0.05). Conclusion Noninvasive ventilation treatment of acute severe bronchial asthma can quickly improve the patient’s respiration, heart rate, blood gas levels, shorten the length of stay, clinical efficacy significantly.