甲基莲心碱1～100μmol/L浓度依赖性地抑制豚鼠左心房收缩性,延长功能性不应期,降低兴奋性;30μmol/L甲基莲心碱能明显提高肾上腺素诱发左心房自律性的阈浓度。对异丙肾上腺素量—效反应的影响,不同于β-受体阻滞剂普萘洛尔,表现为非竞争性拮抗作用,对Ca~(2+)量—效反应的影响,与抗钙剂维拉帕米类似,呈竞争性和非竞争性双重拮抗作用。 Neferine 1 ~ 100μmol / L inhibited the contractility of left atrium in guinea pigs in a concentration-dependent manner, prolonged functional refractory period and decreased the excitability. Thirty (30μmol / L) of neferine significantly increased the threshold of epinephrine-induced left atrial autonomy concentration. The effect of isoproterenol on dose-response is different from that of propranolol, a β-receptor blocker, showing a noncompetitive antagonistic effect on Ca 2+ dose-response, Verapamil is similar to calcium, showing competitive and non-competitive dual antagonism.