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目的:观察环磷酰胺(CTX)冲击疗法治疗成人难治性肾病综合征(1NS)的疗效。方法:选择30例INS患者,均给与CTX冲击治疗。前6个月每月用0.8g加入生理盐水500ml中静滴,以后每3月1次,维持半年至1年停药,总量6～8g,同时合用泼尼松60mg/d,口服6～8周。结果:经以上治疗,24h尿蛋白定量有明显降低,血浆总蛋白和白蛋白不同程度上升,血肌酐无显著差异(P>0.05)。结论:CTX冲击治疗INS疗效显著,缓解率高,副作用小,是治疗该病的较佳方法。
Objective: To observe the effect of cyclophosphamide (CTX) shock therapy in treatment of adult refractory nephrotic syndrome (1NS). Methods: Thirty patients with INS were selected and treated with CTX. The first 6 months with 0.8g per month added saline 500ml intravenous infusion, once every 3 months, to maintain six months to 1 year withdrawal, the total 6 ~ 8g, combined with prednisone 60mg / d, oral 6 ~ 8 weeks. Results: After the above treatment, the urinary protein excretion decreased significantly in 24 h, the plasma total protein and albumin increased to varying degrees, and the serum creatinine had no significant difference (P> 0.05). Conclusion: CTX impact treatment of INS significant effect, high response rate, side effects is small, is a better method of treatment of the disease.