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1984年发表的一组试验研究资料提示,乳腺癌初始手术治疗后给予5年以上三苯氧胺作为辅助性激素治疗是有益的。本文报告了一项随机试验,试验对象为腋淋巴结阳性的手术后乳腺癌患者,术后接受1年化疗和5年三苯氧胺治疗,以评价持续性三苯氧胺治疗5年的效果。 选择194例,其中87例为绝经期后患者,107例为绝经期前患者,随机分为两组。一组持续应用三苯氧胺治疗,另一组为观察组。资料可用于分析者193例,其中87例为绝经期后,106例为绝经期前。平均追踪5.6
A series of experimental studies published in 1984 suggested that it is beneficial to treat tamoxifen for more than 5 years after initial surgical treatment of breast cancer as a supplementary hormone therapy. This article reports a randomized trial of patients with postoperative breast cancer who were positive for axillary lymph nodes. They underwent postoperative chemotherapy for 1 year and tamoxifen for 5 years to evaluate the effect of continuous tamoxifen treatment for 5 years. A total of 194 patients were selected, of whom 87 were postmenopausal patients and 107 were premenopausal patients. They were randomly divided into two groups. One group continued to be treated with tamoxifen and the other group was the observation group. The data can be used to analyze 193 cases, of which 87 cases are postmenopausal and 106 cases are before menopause. Average tracking 5.6