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目的评价硫酸镁在治疗新生儿缺氧缺血性脑病 ( HIE)的疗效。方法 35例新生儿 HIE为治疗组 ,接受综合治疗同时静脉滴注10 %硫酸镁 0 .3ml/( kg· d) ,另 35例只接受综合治疗为对照组。观察疗效 ,并进行新生儿行为神经测定量表 ( NBNA)和 3月龄婴幼儿智能发育量表 ( CDCC)评估。结果 1治疗组总有效率 ( 94.3% )高于对照组 ( 5 7.2 % ) ,有非常显著性差异 ( P<0 .0 1) ;2 NBNA平均得分治疗组 [( 39.5 4± 1.16 )分 ]明显高于对照组 [( 35 .6 5± 3.92 )分 ] ;神经发育指数 ( MBI) ,治疗组 [( 89± 9)分 ]明显高于对照组 [( 80±11)分 ] ;运动发育指数 ( PDI)治疗组 [( 99± 11)分 ]明显高于对照组 [( 89± 10 )分 ] ,两组比较均有非常显著性差异 ( P<0 .0 1)。结论硫酸镁具有神经保护作用。
Objective To evaluate the efficacy of magnesium sulfate in the treatment of neonatal hypoxic-ischemic encephalopathy (HIE). Methods Thirty-five neonates with HIE were treated with combination therapy, while intravenous infusion of 10% magnesium sulfate (0.3 ml / (kg · d)) was given intravenously. The other 35 patients received only combined treatment as the control group. The curative effect was observed and NBNA and 3-month-old infant mental development score (CDCC) were evaluated. Results 1 The total effective rate (94.3%) in the treatment group was significantly higher than that in the control group (52.2%) (P <0.01); 2 NBNA average score [(39.5 4 ± 1.16) (35.66 ± 3.92) points in the control group; the neurological development index (MBI) in the treatment group [(89 ± 9) points] was significantly higher than that in the control group (80 ± 11 points); the motor development The index (PDI) in the treatment group (99 ± 11) was significantly higher than that in the control group (89 ± 10). There was a significant difference between the two groups (P <0.01). Conclusion Magnesium sulfate has neuroprotective effect.