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基因甲基化是基因正常的修饰形式,但是异常基因甲基化是基因失活的一种重要机制,对肿瘤的发生及其发展有重要影响,表现为在肿瘤细胞中整体甲基化程度降低和局部甲基化程度的增高。研究发现许多抑癌基因启动子区域CpG超甲基化与卵巢癌的关系密切。主要就抑癌基因超甲基化与卵巢癌在早期发现、诊断、治疗和预测癌细胞的转移、复发以及提高对抗癌药的敏感性等方面的研究现状作一探讨,并对基因甲基化的研究方向作简要描述。
Gene methylation is a normal form of gene modification, but aberrant gene methylation is an important mechanism of gene inactivation, which has an important influence on the occurrence and development of tumors, as shown by the reduced overall methylation level in tumor cells And the degree of local methylation increased. The study found that many tumor suppressor gene promoter CpG hypermethylation and ovarian cancer are closely related. Mainly on the tumor suppressor gene hypermethylation and ovarian cancer in the early detection, diagnosis, treatment and prognosis of cancer metastasis, recurrence and improve the sensitivity of anti-cancer drugs and other aspects of the current study to make a discussion, and gene methyl A brief description of the research direction.