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目的:探讨乙型肝炎病毒前S1抗原(Pre-S1)与乙型肝炎病毒核酸(HBV-DNA)、e抗原(HBeAg)、e抗体(HBeAb)之间的相关性与临床应用价值。方法:对338例乙型肝炎表面抗原(HBsAg)阳性患者血清进行HBV-DNA、Pre-S1、HBeAg和HBeAb测定并进行分析。结果:检出HBV-DNA阳性200例,Pre-S1阳性182例,HBeAg阳性76例。HBV-DNA阳性患者Pre-S1与HBeAg,阳性率分别为70.00%和35.50%,差异有统计学意义(P<0.01)。在HBVe血清学标志物检测结果中,仅HBeAg阴性而HBeAb阳性组Pre-S1与HBV-DNA阳性率比较差异有统计学意义(P<0.05)。HBV-DNA拷贝数<106时,Pre-S1阳性率高于HBeAg(P<0.05)。结论:随着HBV-DNA拷贝数的增加,Pre-S1和HBeAg的阳性率也增加;Pre-S1检测可作为HBV复制、传染性及肝细胞损伤程度评估,以及对HBeAg阴性乙型肝炎患者诊疗的辅助指标。
Objective: To investigate the correlation and clinical value of Pre-S1 and HBV-DNA, HBeAg and HBeAb in hepatitis B virus (HBV). Methods: The serum HBV-DNA, Pre-S1, HBeAg and HBeAb in 338 patients with HBsAg positive were measured and analyzed. Results: There were 200 cases of positive HBV-DNA, 182 cases of Pre-S1 positive and 76 cases of HBeAg positive. The positive rates of Pre-S1 and HBeAg in HBV-DNA positive patients were 70.00% and 35.50% respectively, with statistical significance (P <0.01). In the results of HBV serological markers, the positive rates of Pre-S1 and HBV-DNA in HBeAg-negative and HBeAb-positive patients were significantly different (P <0.05). The positive rate of Pre-S1 was higher than that of HBeAg when HBV-DNA copy number was less than 106 (P <0.05). Conclusions: The positive rate of Pre-S1 and HBeAg also increased with the increase of HBV-DNA copy number. The Pre-S1 test can be used to evaluate HBV replication, infectiousness and hepatocellular injury, as well as the diagnosis and treatment of HBeAg-negative hepatitis B patients Aid indicators.