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目的：了解高压氧或鼓室内激素对入院治疗超过1周无效的中度以上突发性聋患者的治疗价值。方法对56例收入院治疗1周无效的中度以上突发性聋患者临床资料进行回顾性分析。经激素、改善微循环、营养神经等药物治疗治疗1周无效的患者，根据患者意愿分为鼓室内激素注射治疗组和高压氧治疗组，继续使用改善微循环、营养神经等药物，对两组的短期预后进行比较。结果经使用高压氧或鼓室内激素治疗1周，高压氧组平均听力改善12.7±18.0 dB，鼓室内激素组听力改善13.6±16.5 dB,两组间平均听阈改善差异无统计学差异（t=0.2，p>0.05）。高压氧组治疗有效率为45.2%，鼓室内激素组治疗有效率为48.0%，组间疗效差异无统计学意义（μ=0.54，p>0.05）。发病到开始使用时间7～14天、15～30天、30天以上有效率分别为54.5%、26.7%、37%，组间疗效差异有统计学意义（μ=6.52，p0.05). The efficient in groups of hyperbaric oxygen therapy or intratympanic dexamethasone were 45.2 %,48.0 % separately , which were no significantly different in two groups(μ=0.54,p>0.05). The efficient in SSNHL groups which time from onset to treatment were 7~14days,15~30days,more than one month were 54.5%,26.7%,37%, there was a significant statistic difference among three groups(μ=6.52,p<0.05). Al of the patients were no serious complications.Conclusion:Hyperbaric oxygen therapy or intratympanic dexamethasone treatment is effective for sudden sensorineural hearing loss which is no respect for one week’s treatment. The short-term curative effect are no difference in two treatment.