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目前广泛应用同种异体白细胞免疫治疗习惯性流产(RSA),成功率为70-100%。其机理为正常母亲免疫系统产生的封闭因子或封闭抗体保护胎儿不被免疫排斥,因在RSA患者中缺乏封闭因子,故可输血或接种异体白细胞刺激母亲产生封闭因子。本文作者介绍了用静脉注射多价免疫球蛋白(IVIG)治疗RSA,效果良好。结果如下:对20例RSA患者给予IVIG,从妊娠5周开始,初次剂量0.5-0.6g/kg体重,以后每3周重复注射一次,剂量0.3-0.4g/kg体重,直至妊娠22-24周。结果:其中11例娩出健康婴儿,5例仍在妊娠中,3例妊娠9个月,3例流产,1例异位妊娠,总
Currently widely used allogeneic leukocyte immunotherapy habitual abortion (RSA), the success rate of 70-100%. The mechanism for the normal mother’s immune system to produce blocking factor or blocking antibodies to protect the fetus is not immune rejection, due to the lack of RSA blocking factor in patients, it can be transfused or allogeneic leukocytes stimulate the mother to produce blocking factor. The authors describe the efficacy of intravenous polyvalent immunoglobulin (IVIG) in the treatment of RSA. The results were as follows: 20 patients with RSA were given IVIG, starting from 5 weeks gestation, the initial dose of 0.5-0.6g / kg body weight, repeated every 3 weeks after repeated doses of 0.3-0.4g / kg body weight until 22-24 weeks of gestation . RESULTS: Eleven of these patients delivered healthy infants, 5 were still in pregnancy, 3 had 9 months of gestation, 3 had abortion, 1 had ectopic pregnancy,