鼻窦源性脑脓肿一向被认为是微嗜氧链球菌所致并应用青霉素治疗。本文报告3例均有需氧和厌氧菌混合生长,包括对青霉素耐药的细菌。例一,男20岁,右筛窦炎并眼球突出及眶周蜂窝织炎,行右筛窦切除术及额窦引流,在用青霉素G 和氯霉素治疗期间发生左额窦炎,行探查术发现额窦后壁缺损,加用灭滴灵后仍无好转,又作右额叶脓肿引流,脓液培养出链球菌LancefieldC 型、嗜血杆菌和黑素类杆菌,因病情需要又作了右额叶部分切除术,以后恢复正常。例二,男15岁,因额窦炎用羟氨苄青霉素治疗。又因出现右半侧轻瘫及病灶性抽搐发作经CT 证实为左额叶硬膜外脓肿及左侧全鼻窦炎,行手术排脓,用青霉素G 及磺胺二甲嘧啶治疗期间病情恶化,又 Sinus-derived brain abscess has always been considered to be caused by Streptococcus aeruginosa and the application of penicillin. This report reports three cases of mixed aerobic and anaerobic bacteria, including penicillin-resistant bacteria. Example 1, male 20 years old, right ethmoid sinus and prominent eye and periorbital cellulitis, right ethmoidectomy and frontal sinus drainage, penicillin G and chloramphenicol during the treatment of left frontal sinusitis, probing Surgery found that the frontal sinus posterior wall defects, plus metronidazole still no improvement, but also for the right frontal lobe abscess drainage, Streptococcus Streptococcus LancefieldC-type, Haemophilus and melanobacteria, due to illness needs and made Partial right frontal resection, later returned to normal. Case two, male 15 years old, due to frontal sinusitis with amoxicillin treatment. Because of the emergence of the right hemiparesis and focal convulsions episodes confirmed by CT for the left frontal epidural abscess and left sinusitis, surgical drainage of pus, with penicillin G and sulfamethazine during the treatment of exacerbations, and