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本文报告用赛庚啶(Cyproheptadine)成功地治疗皮质醇增多症一例。患者女,15岁,学生。生长迟缓、向心性肥胖及原发性闭经5年。根据午夜血浆皮质醇、促皮质素浓度和尿类固醇排泄的增加,于1975年12月诊断为皮质醇增多症。X线检查垂体凹正常,静脉肾盂造影伴断层摄片征实肾上腺正常。每天使用地塞米松2毫克不能抑制而改用8毫克才能抑制升高的血浆皮质类固醇。虽应用垂体照射,一年后患者仍无临床及实验室的改善。曾考虑施行全肾上腺切除术,决定每天试用赛庚啶24毫克进行治疗。开始一月内,出现月经并持续规则。满月脸及向心性肥胖逐渐减轻。三个月内,第二性征有明显发
This article reports on the successful treatment of one case of hypercortisol with Cyproheptadine. Female patient, 15 years old, student. Slow growth, central obesity and primary amenorrhea for 5 years. Based on the increase in plasma cortisol, corticosterone concentration, and urinary steroid excretion at midnight, hypercortisolism was diagnosed in December 1975. X-ray examination of the pituitary fovea normal, intravenous pyelography with a normal radiograph of the adrenal gland. Daily use of dexamethasone 2 mg cannot be suppressed and 8 mg is used to suppress elevated plasma corticosteroids. Although pituitary irradiation was used, the patient still had no clinical or laboratory improvement after one year. Having considered performing a total adrenalectomy, it was decided to try cyproheptadine 24 mg daily for treatment. In the first month of January, menstruation began and the rules continued. Full moon face and concentric obesity are gradually reduced. Within three months, the secondary sexual characteristics have obvious