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目的探讨大黄解毒汤治疗口服有机磷农药中毒的临床疗效。方法入选患者227例,危险分层后随机分成2组,A组采用常规治疗,B组在A组基础上配合大黄解毒汤治疗。观察2组患者症状缓解情况、肝功能变化、导泻情况、胆碱酯酶变化、病死率以及迟发性神经病变发生率。结果 B组在缓解症状、充分有效导泻、恢复肝功能及胆碱酯酶、降低病死率等方面效果明显优于A组,在降低迟发性神经病变发生率方面也显示出明显优势。结论大黄解毒汤用于口服有机磷农药中毒疗效明确,中西医结合抢救农药中毒前景广阔。
Objective To investigate the clinical efficacy of rhubarb detoxification decoction in the treatment of oral organophosphorus pesticide poisoning. Methods Totally 227 patients were enrolled in the study. The patients were randomly divided into two groups according to the risk stratification. Group A received conventional treatment and group B received the combination of rhubarb and detoxification on the basis of group A. Two groups of patients were observed symptoms, liver function changes, cathartes, changes in cholinesterase, mortality and the incidence of delayed neuropathy. Results The results of group B were better than group A in relieving symptoms, fully and effectively cathartic, recovering liver function and cholinesterase, reducing mortality and so on. It also showed obvious advantages in reducing the incidence of delayed neuropathy. Conclusion rhubarb detoxification soup for oral organophosphorus pesticide poisoning clear effect, integrated traditional Chinese and Western medicine rescue pesticide poisoning has a bright future.