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鼻用制剂系指直接用于鼻腔发挥局部或全身治疗作用的制剂。由于鼻腔黏膜的特殊生理结构及其独特的吸收机制,导致鼻黏膜给药具有诸多优势:第一,鼻黏膜内血管丰富,鼻黏膜渗透性高,有利于全身吸收;第二,可避开肝脏首过作用、消化道内代谢和药物在胃肠液中的降解;第三,吸收程度和速度有时可与静脉注射相当;第四,鼻腔内给药方便易行。因此,近年来,国内外鼻腔给药制剂发展迅速,降钙
Nasal preparations are preparations that are used directly in the nasal cavity for topical or systemic therapeutic effects. Due to the special physiological structure of the nasal mucosa and its unique absorption mechanism, leading to nasal mucosal administration has many advantages: First, the nasal mucosa rich in blood vessels, nasal mucosa permeability is conducive to systemic absorption; second, to avoid the liver First pass, the metabolism of the digestive tract and the degradation of drugs in gastrointestinal fluids; Third, the degree of absorption and speed can sometimes be equivalent to intravenous injection; Fourth, intranasal administration convenient and easy. Therefore, in recent years, nasal administration at home and abroad rapid development of preparations, reducing calcium