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丙型肝炎病毒(HCV)基因组具有高度的变异性,在机体内以准种的形式存在,尤其以E2/NS1区384-410和474- 480位氨基酸变异程度最高,分别称为HVR1和HVR2。近年的研究发现,HCV准种感染除与引起HCV感染慢性化有关外, 还与HCV对干扰素(IFN)治疗的抵抗作用关系密切。本研究采用克隆测序法对10例应用IFN治疗的1b型慢性丙型肝炎患
Hepatitis C virus (HCV) genome has a high degree of variability and exists in the form of quasispecies in the body, especially the amino acids 384-410 and 474-480 in E2 / NS1 region have the highest degree of variation, which are respectively referred to as HVR1 and HVR2. Recent studies have found that HCV quasispecies infection in addition to causing chronic HCV infection, but also with HCV on the interferon (IFN) treatment of resistance is closely related. In this study, 10 patients with type 1b chronic hepatitis C treated with IFN were treated by cloning and sequencing