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目的探讨缺氧条件下Notch信号通路在滋养细胞中的表达改变。方法利用实时荧光定量PCR(RT-qPCR)技术检测二氯化钴(CoCl2)化学缺氧条件下人早孕绒毛滋养细胞株(the human first-trimester extravillous tropho-blast cell line,TEV-1)中Notch1及Jagged1 mRNA的表达情况。结果 (1)与正常对照组相比,缺氧条件下滋养细胞Notch1 mRNA表达量无明显变化(P>0.05)。(2)随着缺氧时间的延长,滋养细胞Jagged1 mRNA表达量逐渐降低,与正常对照组相比具有统计学意义(P<0.05)。结论缺氧条件下滋养细胞Notch1及Jagged1表达平衡失调,可能参与滋养细胞功能调控。
Objective To investigate the changes of Notch signaling pathway in trophoblast cells under hypoxic condition. Methods Real-time quantitative PCR (RT-qPCR) was used to detect the expression of Notch1 in TEV-1 human primary-trimester extracellular Schwann cell line (TEV-1) And Jagged1 mRNA expression. Results (1) Compared with the normal control group, the expression of Notch1 mRNA in trophoblast did not change significantly under hypoxia (P> 0.05). (2) With the prolongation of hypoxia, the expression of Jagged1 mRNA in trophoblast cells gradually decreased, which was statistically significant compared with the normal control group (P <0.05). Conclusion The imbalanced expression of Notch1 and Jagged1 in trophoblast cells under hypoxia may be involved in the regulation of trophoblast function.