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目的:采用气相色谱法建立5-氯-2-异丙基-4-戊烯酸苯乙胺盐(以下简称SintonB)异构体和手性测定方法。方法:用岛津GC2010型气相色谱,以空气、氢气、氮气、氦气(手性测定)为载气。结果:在50~90mg/mL范围内峰面积与浓度呈良好的线性关系,精密度(RSD=0.16%)良好。该方法重现性、稳定性良好。结论:本方法简便,迅速,准确,专属性强。
OBJECTIVE: To establish a method for the determination of 5-chloro-2-isopropyl-4-pentenoic acid phenylethylamine salt (hereinafter referred to as SintonB) and its chirality by gas chromatography. Methods: Shimadzu GC2010 gas chromatography with air, hydrogen, nitrogen, helium (chiral determination) as a carrier gas. Results: There was a good linear relationship between the peak area and concentration in the range of 50 ~ 90 mg / mL. The precision (RSD = 0.16%) was good. The method is reproducible and has good stability. Conclusion: This method is simple, rapid, accurate and specific.