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应用基因工程技术分别表达出ＳｊＧＳＴＳｊ３２，Ｓｊ３２和ＳｊＧＳＴ，用于保护性免疫的动物实验及其体液免疫机制的初步探讨。结果：与对照组相比，重组ＳｊＧＳＴＳｊ３２组，Ｓｊ３２组，Ｓｊ３２＋ＳｊＧＳＴ组均有明显的减虫效果（Ｐ＜０．０５）。上述三组及ＳｊＧＳＴ组的肝脏虫卵计数均较对照组为少（Ｐ＜０．０１）。提示重组Ｓｊ３２ｋＤ蛋白可诱导小鼠产生明显的抗日本血吸虫攻击感染的保护性免疫及抗生殖免疫效果，而ＳｊＧＳＴ仅表现出一定的抗生殖免疫效果。
Application of genetic engineering technology were expressed SjGST Sj32, Sj32 and SjGST, for the protective immunity of animal experiments and humoral immune mechanism of the preliminary study. Results: Compared with the control group, recombinant SjGSTSj32 group, Sj32 group and Sj32 + SjGST group had significant de-worming effect (P <0.05). The counts of liver eggs in the three groups and the SjGST group were less than those in the control group (P <0.01). These results suggest that the recombinant Sj32kD protein can induce protective immune and anti-reproductive effects in mice against S. japonicum challenge infection, whereas SjGST shows only some anti-reproductive effects.