实质性睑痉挛是一种眼睑不自主性关闭,主要系由轮匝肌的痉挛性收缩所致,降眉间肌和皱眉肌也常参与。其神经解剖学定位和生化机制尚不清楚。实质性睑痉挛是一种独特的、使轮匝肌逐渐衰弱的疾病,由于频繁和长时间的眼睑闭合,常致功能性失明。简单的日常活动,如阅读、写 Essential blepharospasm is an involuntary eyelid closure, mainly caused by the spasm of the orbicularis muscle contraction, lowering the brow and the frown muscle are often involved. Its neuroanatomy localization and biochemical mechanism is not clear. Essential blepharospasm is a unique disease that debilitates the orbicularis muscle, often resulting in functional blindness due to frequent and prolonged eyelid closure. Simple daily activities, such as reading and writing