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本文检测了59例慢性肝炎、肝硬化和肝癌病人的红细胞免疫粘附功能、白细胞介素-2及NK细胞活性等变化。结果显示这些患者的红细胞免疫复合物及循环免疫复合物增高,红细胞C_3b受体花环率降低,外周血白细胞介素-2、NK细胞活性及淋巴细胞转换率明显低于正常人,尤以HBV—DNA、HBeAg及HBsAg三者阳性者降低更为显著。提示HBV感染时白细胞介素-2、NK细胞活性等细胞免疫功能下降,以致使机体清除HBV的功能障碍。
In this paper, 59 cases of chronic hepatitis, cirrhosis and liver cancer patients erythrocyte immune adhesion function, interleukin -2 and NK cell activity changes. The results showed that these patients increased erythrocyte immune complexes and circulating immune complexes, erythrocyte C_3b receptor rosette decreased peripheral blood interleukin -2, NK cell activity and lymphocyte conversion rate was significantly lower than normal, especially in HBV- DNA, HBeAg and HBsAg positive three were more significantly reduced. Prompt HBV infection, interleukin -2, NK cell activity and other cellular immune function decreased, so that the body cleared of HBV dysfunction.