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目的观察联合α-2b干扰素治疗轮状病毒肠炎的疗效和不良反应。方法对确诊的轮状病毒肠炎的90例患儿随机分为常规治疗组,α-2b干扰素组和联合治疗各30例,疗程5～7d,比较3组患儿止泻时间,退热时间及显效率与总有效率。结果常规组,α-2b干扰素组,联合治疗组患儿止泻时间分别为(4.76±2.21)d,(4.53±1.84)d,(3.21±0.87)d;退热时间分别为(32.5±7.4)h,(29.3±5.8)h,(22.4±4.6)h,α-2b干扰素与常规组比较差异无统计学意义,联合治疗组较常规组和α-2b干扰素明显缩短,差异有统计学意义。联合治疗组显效率及总有效率分别为80.0%,96.7%,明显优于常规组和α-2b干扰素组,差异有统计学意义,结论复方胃蛋白酶治疗少儿轮状病毒性肠炎可明显缩短腹泻及发热时间,提高疗效。
Objective To observe the efficacy and adverse reactions of combined interferon α-2b in the treatment of rotavirus enteritis. Methods 90 cases of diagnosed rotavirus enteritis were randomly divided into routine treatment group, α-2b interferon group and combination therapy of 30 cases, the treatment of 5 ~ 7d, compared 3 groups of children with diarrhea time, antipyretic time And significant efficiency and total efficiency. Results The antidiarrheal time of the conventional group, α-2b interferon group and the combined treatment group were (4.76 ± 2.21) days and (4.53 ± 1.84) days and (3.21 ± 0.87) days, respectively. The antipyretic time were (32.5 ± 7.4) h, (29.3 ± 5.8) h and (22.4 ± 4.6) h, respectively. There was no significant difference between the interferon α-2b and the conventional group, and the combined treatment group was significantly shorter than the conventional group and interferon α-2b Statistical significance. The combined treatment group markedly effective and total effective rate was 80.0%, 96.7%, significantly better than the conventional group and interferon α-2b group, the difference was statistically significant, Conclusion compound pepsin treatment of children with rotavirus enteritis can be significantly reduced Diarrhea and fever time, improve the curative effect.