论文部分内容阅读
目的：探讨葡萄糖转运蛋白（ＧＬＵＴ１）基因多态性与糖尿病及糖尿病肾病（ＤＮ）的关系。方法：应用ＰＣＲ方法对１３１例Ⅱ型糖尿病（ＮＩＤＤＭ）患者ＧＬＵＴ１基因多态性与ＮＩＤＤＭ及ＤＮ发生之间的关系进行了观察，并结合患者体重指数（ＢＭＩ）和胰岛素敏感指数（ＩＳＩ）进行分析。结果：①ＮＩＤＤＭ组患者ＸｂａＩ（＋／－）基因型的发生频率明显高于正常人群（６２％ｖｓ３３％，Ｐ＜０．０１），而ＸｂａＩ（＋／＋）基因型的发生频率则明显低于正常人群（３１％ｖｓ６２％，Ｐ＜０．０１）。ＮＩＤＤＭ患者ＸｂａＩ（－）等位基因的发生频率明显高于正常人群（３８％ｖｓ２１％，Ｐ＜０．０１），而ＸｂａＩ（＋）等位基因型的发生频率则明显低于正常人群（６２％ｖｓ７９％，Ｐ＜０．０１），ＸｂａＩ（－）等位基因与ＮＩＤＤＭ明显相关（ＯＲ２．１９９，９５％可信限１．４７６～３．２７７）；②ＤＮ（＋）组患者ＸｂａＩ（＋／－）基因型的发生频率明显高于ＤＮ（－）组（７５％ｖｓ４４％，Ｐ＜０．０１），而ＸｂａＩ（＋／＋）基因型的发生频率则明显低于ＤＮ（－）组（１９％ｖｓ４９％，Ｐ＜０．０１）。ＤＮ（＋）组患者ＸｂａＩ（－）等位基因的发生频率明显高于ＤＮ（－?
Objective: To investigate the relationship between glucose transporter (GLUT1) gene polymorphism and diabetic and diabetic nephropathy (DN). Methods: The relationship between GLUT1 gene polymorphisms and the occurrence of NIDDM and DN in 131 cases of type 2 diabetes mellitus (NIDDM) patients was observed by PCR and analyzed with the patients’ body mass index (BMI) and insulin sensitivity index (ISI) . Results: ①The frequency of XbaI (+/-) genotype in patients with NIDDM was significantly higher than that in normal people (62% vs33%, P <0.01), while the frequency of XbaI (+ / +) genotype was significantly lower than Normal population (31% vs62%, P <0.01). The frequency of XbaI (-) alleles in patients with NIDDM was significantly higher than that in normal subjects (38% vs 21%, P <0.01), while the frequency of XbaI alleles was significantly lower than that in controls % Vs79%, P <0.01). XbaI (-) allele was significantly associated with NIDDM (OR2.199, 95% confidence interval, 1.476-3.277) / Genotype was significantly higher than that of DN group (75% vs44%, P <0.01), while the frequency of XbaI (+ / +) genotype was significantly lower than that of DN (-) group (19% vs 49%, P <0.01). The frequency of XbaI (-) allele in DN (+) group was significantly higher than that in DN (-?