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目的探讨老年高血压患者血清同型半胱氨酸(homocysteine,Hcy)水平对患者认知功能的影响。方法 143例老年高血压患者采用循环酶法检测血清Hcy水平,并进行简短精神状态量表(Mini-mental State Examination,MMSE)测定,根据血清Hcy水平分为高Hcy组(Hcy>20μmol/L)67例和正常Hcy组(Hcy≤20μmol/L)76例,比较2组MMSE量表评分。结果高Hcy组患者MMSE评分[(24.02±4.97)分]低于正常Hcy组[(28.73±4.61)分],2组比较差异有统计学意义(P<0.05)。结论血清Hcy水平升高可加重老年高血压患者认知功能损害。
Objective To investigate the effect of homocysteine (Hcy) on cognitive function in elderly hypertensive patients. Methods Serum Hcy levels were measured by circulating enzymatic assay in 143 elderly patients with hypertension. The levels of Hcy were determined by Mini-mental State Examination (MMSE) 67 cases and normal Hcy group (Hcy≤20μmol / L) 76 cases, MMSE scale scores of two groups were compared. Results The scores of MMSE in high Hcy group [(24.02 ± 4.97) points] were lower than those in normal Hcy group [(28.73 ± 4.61) points). There was significant difference between the two groups (P <0.05). Conclusion Serum Hcy levels may aggravate cognitive impairment in elderly patients with hypertension.