We proposed an efficient scheme for implementing the large-scale one-way Quantum computing(QC)with a novel hybrid solid-state quantum system. This system consists of N Nitrogen-vacancy(N-V) centers coupled to N separate Transmission line resonators(TLRs), which are interconnected by a Current-biased Josephson junction(CBJJ) superconducting phase qubit. We showed the way of preparation of N-qubit linear cluster state with N N-V centers, then we demonstrated the way of extending cluster state by connecting two pieces of linear cluster states into two-dimensional cluster state, last, with our designed new structures, we demonstrated the QC basic operations.It means that our scheme may open up promising possibilities for implementing the practical and scalable one-way quantum computers with the hybrid solid-state quantum system. We discussed the experimental feasibility of our system. We propose an efficient scheme for implementing the large-scale one-way Quantum computing (QC) with a novel hybrid solid-state quantum system. This system consists of N Nitrogen-vacancy (NV) centers coupled to N separate Transmission line resonators (TLRs ), which are interconnected by a Current-biased Josephson junction (CBJJ) superconducting phase qubit. We showed the way of preparation of N-qubit linear cluster state with N NV centers, then we demonstrated the way of extending cluster state by connecting two pieces of linear cluster states into two-dimensional cluster state, last, with our designed new structures, we demonstrated the QC basic operations. It means that our scheme may open up promising for implementing the practical and scalable one-way quantum computers with the hybrid solid-state quantum system. We discussed the experimental feasibility of our system.