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目的研究黄芪苷Ⅳ（ＸＧＡ）对损伤的人血白细胞变形能力的影响。方法人血白细胞经孵化后损伤，用核孔膜滤过法观察ＸＧＡ对白细胞变形能力的影响，并在电镜下观察白细胞形态的变化。结果人血白细胞在孵化２４及４８ｈ后受到损伤，白细胞阻塞率（ＣＩ）值明显增加，５０μｇ／ｍｌ样品的ＸＧＡ对损伤的白细胞能明显降低其ＣＩ值，改善白细胞的变形能力；ＸＧＡ在２５～２５０μｇ／ｍｌ样品的剂量范围内对损伤的白细胞均能明显降低其ＣＩ值，改善白细胞的变形能力；电镜下观察到５０μｇ／ｍｌ样品的ＸＧＡ对损伤的白细胞有修复作用。结论ＸＧＡ能明显改善受损白细胞的变形能力，而白细胞变形能力的改善可能是ＸＧＡ防治心脑血管疾病的作用机制之一。
Objective To study the effect of Xylatranol (XGA) on the deformability of injured human leukocytes. Methods Human leukocytes were injured after incubation. The effect of XGA on the deformability of leukocytes was observed by nuclear membrane filtration. The morphology of leukocytes was observed under electron microscope. Results Human leucocytes were damaged after 24 and 48 hours of incubation, and the leukocyte occlusion rate (CI) increased obviously. The XGA of 50μg / ml samples could significantly reduce the CI of injured leukocytes and improve the deformability of white blood cells. In the range of 250μg / ml, the damage of leucocytes could be significantly reduced and the deformability of leucocytes was improved. The XGA of 50μg / ml could repair the damaged leucocytes. Conclusion XGA can significantly improve the deformability of injured leukocytes, while the improvement of white blood cell deformability may be one of the mechanisms of XGA in prevention and treatment of cardiovascular and cerebrovascular diseases.