钙依赖粘附素是细胞之间粘附连接的重要组成分子 ,在发育及成年机体的组织结构中起着重要作用。钙依赖粘附素细胞外段决定其结合的特异性 ,其胞浆尾段与胞浆相关蛋白及细胞骨架的相互作用和联系对完整的生理性粘附也必不可少。粘附连接的调节涉及到钙依赖粘附素的量和质变化 ;此外 ,钙依赖粘附素 连环素复合体参与信号转导过程 ,并影响组织的结构和功能。 Calcium-dependent adhesins are important components of adhesion and adhesion between cells and play an important role in the development and organization of adult body. Calcium-dependent adhesin extracellular segments determine the specificity of its binding, and its cytoplasmic tail and cytoplasmic proteins and cytoskeletal interactions and connections are also essential for complete physiological adhesion. The regulation of adhesion junctions involves the amount and qualitative changes of calcium-dependent adhesins; in addition, the calcium-dependent adhesin-catenin complex is involved in the signal transduction process and affects the structure and function of the tissue.