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目的探讨米索前列醇联合缩宫素在预防及减少产后出血中的的临床疗效.方法选择足月妊娠产妇200例,随机分为对照组和观察组,两组产妇均于胎儿娩出后立即给药,对照组给予单纯缩宫素治疗,治疗组在对照组基础上加用米索前列醇200μg 舌下含服,比较两组临床疗效.结果观察组子宫收缩明显加强,产后出血量明显少于对照组,两组差异具有统计学意义(P<0.05),对照组未见明显不良反应,观察组中14例出现寒战、发烧.结论米索前列醇联合缩宫素能有效减少产后出血,优于单用缩宫素,值得临床推广应用.“,”Objective To study of misoprostol combined with oxytocin in the prevention and reduction of postpartum hemorrhage of clinical effect. Methods t pregnancy in 200 cases, were randomly divided into control group and observation group with 100 cases in each group, two groups were immediately after delivery of maternal fetal medicine, the control group was given simple oxytocin treatment, the observation group in the control group plus misoprostol 200μ g sublingual, comparison of two clinical curative effect. Results the observation group was significantly enhanced contraction of the uterus, postpartum hemorrhage volume was significantly less than that in the control group, the difference between the two groups was significant ( P<0.05 ), the observation group there was no obvious adverse reaction, a control group of 4 patients had chil, cold extremities, mild nausea, vomiting and other symptoms, symptomatic treatment after remission of symptoms. Conclusion misoprostol combined with oxytocin may be effective in reducing postpartum hemorrhage, is better than the single use of oxytocin, worthy of clinical application.