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为研究急、慢性疼痛与血浆β－内啡肽含量的关系，本研究随机选取急腹症和慢性脊神经痛病人，在治疗前后分别采取血样，对其β－内啡肽含量进行检测，并与无痛志愿者的检测结果相对比。结果表明：（１）急腹症病人血浆β－内啡肽含量较正常无痛者稍高，但无显著性差异（Ｐ＞０．０５）；经治疗疼痛消失后，虽然降低了２０％，但与治疗前及正常无痛组对照，仍无统计学差异（Ｐ＞０．０５）。（２）慢性脊神经痛组病人的血浆β－内啡肽含量显著低于无痛对照组（Ｐ＜０．００１）；经治疗后，疼痛ＮＲＴ－１１评分较治疗前显著降低（Ｐ＜０．０１），血浆β－内啡肽含量亦稍有降低，但无统计学意义（Ｐ＞０．０５）。（３）对各变量的相关性分析发现，慢性脊神经痛患者治疗后疼痛评分的降低值与血浆β－内啡肽含量的降低值呈正相关（Ｐ＜０．０５）。我们认为，血浆β－内啡肽含量偏低可能是慢性脊神经痛患者罹患疼痛的重要原因之一；血浆β－内啡肽可能与机体的抗痛能力有关。
In order to study the relationship between acute and chronic pain and plasma β-endorphin content, this study randomly selected acute abdomen and chronic spinal neuralgia patients, blood samples were taken before and after treatment to detect β-endorphin content, and with Painless volunteers test results compared to. The results showed that: (1) The content of plasma β-endorphin in patients with acute abdomen was slightly higher than that of normal painless patients (P> 0.05); after the treatment pain disappeared, although it decreased by 20% However, there was no significant difference between pretreatment and normal painless group (P> 0.05). (2) The content of plasma β-endorphin in chronic spinal neuralgia group was significantly lower than that in painless control group (P <0.001). After treatment, NRT-11 score of pain decreased significantly (P <0. 01), plasma β-endorphin levels also decreased slightly, but not statistically significant (P> 0.05). (3) Correlation analysis showed that there was a positive correlation between the reduction of post-treatment pain score and the decrease of plasma beta-endorphin level in patients with chronic spinal neuralgia (P <0.05). In our opinion, the low plasma β-endorphin level may be one of the important causes of pain in patients with chronic spinal neuralgia. Plasma β-endorphin may be related to the body’s anti-pain ability.