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B淋巴细胞主要通过产生各种抗体和呈递抗原发挥免疫调节作用。研究表明,B淋巴细胞中存在着一些能够调节免疫应答的新细胞亚群——调节性B细胞,其主要是通过产生白细胞介素10(IL-10)和转化生长因子β(TGF-β)等抑制性细胞因子发挥免疫负向调节作用,在艾滋病病毒(HIV)感染中具有重要作用。对HIV感染者调节性B细胞表型和功能等的研究,将为深入了解艾滋病发病机制和治疗方法提供新的理论依据和研究方向。
B lymphocytes play an immunomodulatory role primarily by producing various antibodies and presenting antigens. Studies have shown that there are some new cell subsets that regulate immune responses in B lymphocytes, regulatory B cells, which are mainly produced through the production of interleukin 10 (IL-10) and transforming growth factor beta (TGF-beta) Inhibitory cytokines and other negative immune regulation play a role in HIV infection. Research on the phenotype and function of regulatory B cells in HIV-infected patients will provide new theoretical basis and research direction for understanding the pathogenesis and treatment of AIDS.