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作者们报告了以博莱霉素、环磷酰胺、氨甲蝶呤、5氟脲嘧啶(简称Bleo-CMF方案)治疗晚期头颈部鳞癌的经验。共39例病人(男28,女11,年龄43～83岁),其中33例为放疗后复发。本组病例的选择,不论以前接受过何种治疗,一般状态及肿瘤情况如何,只要符合下述标准即可:(1)组织学证实为头颈部鳞癌(不包括原发于食管者);(2)Ⅲ和Ⅳ期癌;(3)外周血象的细胞计数>4,000/mm~3,血小板计数>10万/mm~3;(4)血尿素氮<25mg％,血清肌酐<1.5 mg％;(5)存在可测量大小之肿瘤;(6)过去未用过博莱霉素。给药方法:博莱霉素15单位/日,静脉注入(30例)或皮下注射(9例),连用3天,第4天休息;第5天静脉给予环磷酰胺500 mg,氨
The authors reported on the experience with bleomycin, cyclophosphamide, methotrexate, and 5-fluorouracil (Bleo-CMF for short) treatment for advanced head and neck squamous cell carcinoma. A total of 39 patients (male 28, female 11, age 43-83 years), 33 of whom relapsed after radiotherapy. The selection of this group of patients, regardless of what kind of treatment has been received before, the general state and the condition of the tumor, as long as the following criteria can be met: (1) histologically confirmed head and neck squamous cell carcinoma (excluding primary esophagus) (2) Stages III and IV cancer; (3) Peripheral blood cell count > 4,000/mm~3, platelet count >10 000/mm~3; (4) Blood urea nitrogen <25 mg%, serum creatinine <1.5 mg %; (5) tumors of measurable size; (6) bleomycin has not been used in the past. Dosing method: Bleomycin 15 units/day, intravenous injection (30 cases) or subcutaneous injection (9 cases), continuous use for 3 days, rest on the 4th day; 5th day of intravenous administration of cyclophosphamide 500 mg, ammonia