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目的 :探讨慢性乙肝患者治疗初期CEA和AFP的水平与治疗48周后获得生化应答之间是否存在相关性,从而为临床治疗提供重要的理论基础和参考依据。方法 :在治疗不同时段对72例CHB患者进行血清CEA、AFP、ALT水平检测,并判断是否发生生化应答。结果 :0周CEA水平与治疗36周和48周后是否获得生化应答之间存在负相关性;0周AFP水平与治疗48周后是否获得生化应答之间也存在负相关性。结论 :治疗初始CEA、AFP水平高低可以作为预测患者经48周治疗后可否获得BR的参考指标之一,治疗初期检测患者CEA、AFP水平有利于全面监测CHB病情、提高治疗效果。
Objective: To investigate the correlation between the level of CEA and AFP in patients with chronic hepatitis B and the biochemical response after 48 weeks of treatment, so as to provide an important theoretical basis and reference for clinical treatment. Methods: Serum levels of CEA, AFP and ALT were measured in 72 CHB patients at different periods of treatment and the biochemical response was determined. Results: There was a negative correlation between 0-week CEA level and whether biochemical response was obtained after 36 weeks and 48 weeks of treatment. There was also a negative correlation between 0-week AFP level and biochemical response after 48 weeks of treatment. Conclusion: The initial CEA and AFP levels can be used as one of the reference indexes for predicting BR after 48 weeks of treatment. The detection of CEA and AFP in the initial stage of treatment can be helpful for the comprehensive monitoring of CHB and improve the therapeutic effect.