在过去10多年中,细菌对抗生素的耐药性发展仍然很快,病原菌在其求生存的战斗中具有惊人的适应性,一次又一次地给临床抗菌药物的应用造成了许多几乎无法解决的严重问题。临床迫切需要抗生素的更新换代。 Over the past 10 years, the development of bacterial resistance to antibiotics has continued to grow rapidly. The phenomenal adaptability of pathogens in their battle for survival has resulted in time and again many serious and intractable problems in the use of clinical antimicrobials problem. The urgent need for clinical replacement of antibiotics.