The optimal treatment for patients with nephroblastoma and inferior vena cava (IVC) tumor thrombus is radical nephrectomy and tumor thrombectomy, but the operation for patients with level Ⅲ tumor thrombus is usually at high risk of pulmonary embolism (PE). We report one case of nephroblastoma with level Ⅲ thrombus in our hospital in 2007, the vena cava tumor thrombectomy was safely performed under the protection of Tempofilter Ⅱ inferior vena cava filter.