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伟大领袖毛主席教导我们:“唯物辩证法认为外因是变化的条件,内因是变化的根据,外因通过内因而起作用。” 链霉素具有耳毒性。但是,并不是每一个使用链霉索的人都会发生耳聋。临床上经常遇到,有的病人长期使用,并未显示其对听神经的毒性;可是另有一些病人,刚用几克,听力就减退,敏感性很高。这是为什么呢?聋哑研究组同志在辽源聋哑病医院开门搞科研的过程中,发现这类病人有不少是携儿带女一家数人同时前来求治的。这就给了一个印象:“链霉素致聋可能与易感家族有关。”为了搞清这个问题,他们对101名链霉素中毒性耳聋病人进行了调查,发现人群中一部分易感家族听觉器官比较脆弱,易于受外界致聋因素(包括链霉素等耳毒性抗菌素)的损伤。如他们曾发现一个家族中有各种耳聋者多达10人,显示出本病的遗传性,而且可能主要通过母系遗传。事实证明,在链霉素中毒性耳聋的发病上,外因是通过内因起作用的。 这一现象的揭示,在临床上是有意义的。它启示我们,使用链霉素时,应注意家族中毒史,对易感家族成员,要尽量不用、少用或慎用链霉素;即使治疗需要,一定要用时,也要加强听力监护,以预防耳聋的发生。
The great leader Chairman Mao teaches us: “Materialist dialectics believe that external factors are conditions of change, internal factors are the basis of change, and external factors work through internal factors.” Streptomycin has ototoxicity. However, not every person who uses streptomycin can develop deafness. Clinically often encountered, some patients long-term use, did not show its toxicity to the auditory nerve; but some patients, just a few grams, hearing loss, high sensitivity. Why is this? Deaf mute study group in Liaoyuan deaf-mute hospital to open the door of scientific research process and found that many of these patients are brought with children and a number of women come to seek treatment at the same time. This gives the impression that “streptomycin-induced deafness may be associated with susceptible families.” To figure this out, they investigated 101 people with streptomycin-detoxifying deafness and found that some of the susceptible families in the population were hearing Organ is more vulnerable and vulnerable to deafness caused by external factors (including streptomycin and other ototoxic antibiotics) damage. If they have found that there are a variety of deaf in a family up to 10 people, showing the hereditary disease, and may be mainly maternally inherited. Facts have proved that in the pathogenesis of streptomycin toxic deafness, the external cause is through the internal factors. The revelation of this phenomenon is clinically meaningful. It suggests that when using streptomycin, we should pay attention to the history of familial poisoning. For members of susceptible families, we should try our best not to use or use less streptomycin. Even if treatment needs, we must strengthen the monitoring of hearing to Prevent deafness.