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目的观察氟比洛芬酯脂微球载体注射液(商品名凯纷)治疗老年癌痛的疗效和副作用。方法 47例不能耐受阿片类药物或阿片类药物效果不佳的癌性疼痛患在2周的时间内者每天静脉注射50～100 mg氟比洛芬酯脂微球载体注射液,分别就其疗效、生活质量改善情况以及不良反应等方面进行全面评价。结果氟比洛芬酯脂微球载体注射液治疗老年癌痛的有效率为87.23%(PR+CR),生活质量改善情况治疗前后差异有统计学意义(P<0.05)。但未见一般非甾体类药物常见腹痛、消化道出血等副作用;也未见便秘、恶心、呕吐、嗜睡、血压下降等阿片类药物常见不良反应。结论氟比洛芬酩脂微球载体注射液治疗老年癌痛疗效可靠,生活质量可得到改善,氟比洛芬酯脂微球载体注射液不良反应发生率较低,为临床止痛药物的选择提供了一个新途径。
Objective To observe the efficacy and side effects of flurbiprofen ester lipid microsphere carrier injection (trade name Triptych) in the treatment of senile cancer pain. Methods Forty-seven patients with cancerous pain who were unable to tolerate opioids or opioids were treated with a daily intravenous injection of 50-100 mg flurbiprofen liposome-loaded microsphere carrier solution within 2 weeks, Efficacy, quality of life to improve the situation and adverse reactions and other aspects of a comprehensive evaluation. Results The effective rate of flurbiprofen ester microspheres carrier injection in the treatment of senile cancer pain was 87.23% (PR + CR), and there was significant difference in quality of life before and after treatment (P <0.05). But no common non-steroidal drugs common abdominal pain, gastrointestinal bleeding and other side effects; nor constipation, nausea, vomiting, lethargy, blood pressure and other opioid adverse reactions common. CONCLUSION: Flurbiprofen liposome-loaded microspheres carrier injection is effective in treating elderly patients with cancer pain and the quality of life can be improved. The incidence of adverse reactions in flurbiprofen ester microspheres carrier injection is relatively low, which provides the choice of clinical pain medication A new way.