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偏头痛是一种常见病,其特征是单边头痛,并伴有恶心、呕吐和胃肠道功能紊乱。长期以来都认为偏头痛的发病机理主要是血管性的,且与明显的长时间脑血管扩张有关。但这个概念近来已出现问题。至少是已有多种事实无疑地显示5-HT与偏头痛的病因有关,一个明显的例子就是许多偏头痛治疗药是影响5-HT受体的。我们的研究是假设具有血管收缩活性的选择性5-HT_1样受体激动剂对偏头痛有效,但这一假定并非基于5-HT或其它任何介质的水平变化与疾病过程有关的事实,而是基于血管收缩剂已经显示能消除偏头痛的发作。事实上,静脉注射5-
Migraine is a common disease characterized by unilateral headache associated with nausea, vomiting and gastrointestinal disorders. The pathogenesis of migraine has long been thought to be primarily vascular, and is associated with significant prolonged cerebrovascular dilation. But this concept has been a problem lately. There are, at the very least, a number of facts that have undoubtedly shown that 5-HT is involved in the etiology of migraine. An obvious example is that many migraine remedies affect 5-HT receptors. Our study hypothesized that selective 5-HT1-like receptor agonists with vasoconstrictor activity are effective in migraine but this assumption is not based on the fact that the level of 5-HT or any other mediator changes in relation to the disease process, but instead Vasoconstrictor agents have been shown to eliminate the onset of migraine. In fact, intravenous 5-