论文部分内容阅读
近几年来,国内对Norplant(D-甲炔诺酮埋植剂)皮下埋植进行了临床观察和对免疫影响研究,但运用姊妹染色单体互(SCE)和染色体畸变指标对受试者的细胞染色体是否致畸变作用迄今报道甚少.本文分析了20例Norplant皮下埋植妇女埋植前、埋植后6个月及12个月SCE值和染色体畸变率的动态观察,分别与20例对照组比较均无统计学意义.结果表明Norplant埋植剂可能无明显增高SEC和染色体畸变的作用,埋植后妇女换SCE不随着用药年限延长而增加.未见有可察觉的致突变、致癌等遗传效应.
In recent years, Norplant (D-norgestone implants) subcutaneous implants were observed and the impact of immune studies, but the use of sister chromatid interaction (SCE) and chromosomal aberrations index of the subjects Cell chromosome aberration caused by so far little reported.This paper analyzes the 20 cases of Norplant subcutaneously implanted women before implants, 6 months and 12 months after implantation SCE value and chromosome aberration rate dynamic observation, respectively, and 20 cases of control The results showed that Norplant implants may not significantly increase the role of SEC and chromosomal aberrations, after implantation, the change of SCE does not increase with the extension of the medication .No obvious mutagenicity, carcinogenesis, etc. Genetic effects.